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Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.
McCarthy N, Manieri E, Storm EE, Saadatpour A, Luoma AM, Kapoor VN, Madha S, Gaynor LT, Cox C, Keerthivasan S, Wucherpfennig K, Yuan GC, de Sauvage FJ, Turley SJ, Shivdasani RA. McCarthy N, et al. Among authors: kapoor vn. Cell Stem Cell. 2020 Mar 5;26(3):391-402.e5. doi: 10.1016/j.stem.2020.01.008. Epub 2020 Feb 20. Cell Stem Cell. 2020. PMID: 32084389 Free PMC article.
IL-1R1-dependent signaling coordinates epithelial regeneration in response to intestinal damage.
Cox CB, Storm EE, Kapoor VN, Chavarria-Smith J, Lin DL, Wang L, Li Y, Kljavin N, Ota N, Bainbridge TW, Anderson K, Roose-Girma M, Warming S, Arron JR, Turley SJ, de Sauvage FJ, van Lookeren Campagne M. Cox CB, et al. Among authors: kapoor vn. Sci Immunol. 2021 May 7;6(59):eabe8856. doi: 10.1126/sciimmunol.abe8856. Sci Immunol. 2021. PMID: 33963061
Gremlin 1+ fibroblastic niche maintains dendritic cell homeostasis in lymphoid tissues.
Kapoor VN, Müller S, Keerthivasan S, Brown M, Chalouni C, Storm EE, Castiglioni A, Lane R, Nitschke M, Dominguez CX, Astarita JL, Krishnamurty AT, Carbone CB, Senbabaoglu Y, Wang AW, Wu X, Cremasco V, Roose-Girma M, Tam L, Doerr J, Chen MZ, Lee WP, Modrusan Z, Yang YA, Bourgon R, Sandoval W, Shaw AS, de Sauvage FJ, Mellman I, Moussion C, Turley SJ. Kapoor VN, et al. Nat Immunol. 2021 May;22(5):571-585. doi: 10.1038/s41590-021-00920-6. Epub 2021 Apr 26. Nat Immunol. 2021. PMID: 33903764
Toripalimab, a therapeutic monoclonal anti-PD-1 antibody with high binding affinity to PD-1 and enhanced potency to activate human T cells.
Rajasekaran N, Wang X, Ravindranathan S, Chin DJ, Tseng SY, Klakamp SL, Widmann K, Kapoor VN, Vexler V, Keegan P, Yao S, LaVallee T, Khare SD. Rajasekaran N, et al. Among authors: kapoor vn. Cancer Immunol Immunother. 2024 Feb 24;73(3):60. doi: 10.1007/s00262-024-03635-3. Cancer Immunol Immunother. 2024. PMID: 38400933 Free PMC article.
Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.
Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, Manning BD, Sharpe AH, Haining WN, Turley SJ. Brown FD, et al. Among authors: kapoor vn. Nat Immunol. 2019 Dec;20(12):1668-1680. doi: 10.1038/s41590-019-0515-x. Epub 2019 Oct 21. Nat Immunol. 2019. PMID: 31636464 Free PMC article.
Testosterone is an endogenous regulator of BAFF and splenic B cell number.
Wilhelmson AS, Lantero Rodriguez M, Stubelius A, Fogelstrand P, Johansson I, Buechler MB, Lianoglou S, Kapoor VN, Johansson ME, Fagman JB, Duhlin A, Tripathi P, Camponeschi A, Porse BT, Rolink AG, Nissbrandt H, Turley SJ, Carlsten H, Mårtensson IL, Karlsson MCI, Tivesten Å. Wilhelmson AS, et al. Among authors: kapoor vn. Nat Commun. 2018 May 25;9(1):2067. doi: 10.1038/s41467-018-04408-0. Nat Commun. 2018. PMID: 29802242 Free PMC article.